Education has played an important role at St. Joseph's Hospital, almost since its inception. The program was formalized in 1872, when students at Syracuse University's College of Medicine were granted clinical instruction privileges at the hospital. As a teaching facility, St. Joseph's must keep on top of the latest knowledge in medicine as well as the newest in technology in order to attract "the brightest and the best."

Through affiliation with a number of other educational institutions, the hospital serves as a clinical teaching setting for Licensed practical nursing, Medical social services, Medical technology, Physical therapy, Physician's assistants (including an affiliation as the primary clinical setting for students in LeMoyne College's new physician assistant program), Professional nursing, Respiratory therapy, and X-ray technology.

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